How it works
How Naltrexone Works
Naltrexone doesn’t make you sick if you drink. It takes the shine off — so “just one more” is easier to skip.
Drinking lights up reward pathways in the brain. Naltrexone occupies those receptors so the buzz is quieter. The night can still be a night. It just doesn’t have to run away with you.
What people notice
Finishing a glass and actually feeling done. Saying yes to dinner and no to the third round. Waking up with the morning still intact.
Naltrexone is an FDA-approved prescription. It is a tool, not a personality transplant — and it works best with a clinician who helps you pick a pace that fits your life.
Do I have to quit?
Not unless you want to. Plenty of people use naltrexone to drink less, not stop. Your clinician helps you set a goal that feels honest.
How you take it
Oral naltrexone is typically a daily pill. Some people take it before drinking occasions, if that’s the plan their clinician sets. Follow the instructions you are given — dosing is a clinical decision, not a DIY protocol.
A few important notes
- It does not reverse intoxication.
- It is not emergency care. If you have a medical emergency, call 911.
- Tell your clinician if you take opioid medications — naltrexone is often not a fit in that case.
How Siplo fits in
We connect you with a licensed clinician. If naltrexone is a match, a 90-day supply ships to you. $79/month, billed once ($237). You’re only charged if a clinician says it’s a fit.
Ready for a lighter next 90 days?
Three minutes to get started. A clinician decides if naltrexone is a fit.
Get Started